The VHP sterilization system of Trane Bio-Air Conditioning System adopts the most advanced VHP sterilization process technology to provide domestic users with the most professional, versatile and customized VHP sterilization system. Through continuous research and development, we constantly update our products and technologies, and apply new technologies to our air-conditioning VHP sterilization systems to benefit our customers.

Our products have been selected by many of the country's most well-known biopharmaceutical companies, laboratories, research institutions, universities and government departments. The product quality of the Trane Biologics brand and the dedication of our employees have created today's success, and we will never stop in the pursuit of professionalism.

We not only provide standard VHP sterilization equipment, we also provide customized designs, rich options and supporting services to meet international certification requirements such as FDA, EU and WHO.

Supporting options: audit trails; electronic signatures; electronic records (PDF reports); remote control options, etc.

Supporting services: installation and commissioning services, IQ/OQ/PQ verification services, preventive maintenance and spare parts supply.

1. Low operating costs: Our products have no special parts and all spare parts can be purchased on the market;

2. Rich options and customized production: We have standardized the types and options of VHP sterilizers, and can provide a wide range of options according to customers' needs. We can also provide customized production according to customers' actual conditions to meet customers' sterilization needs;

3. Real-time monitoring and data storage: It can realize equipment data storage, sterilization cycle reminder and abnormal alarm, as well as real-time monitoring of equipment;

4. Easy to use: It adopts a humanized and user-friendly interface design, so even people who have never used it can operate it without any barriers after simple training;

5. Dry process: Trane Bio VHP sterilizer uses process saturation control and dew point monitoring to ensure that the VHP in the entire sterilization process does not condense from the generation, disinfection and degradation stages to the vaporization state of the entire process.

Trane BioVHP generator uses low-temperature flash evaporation to vaporize high-concentration hydrogen peroxide, and the generator uses standardized modules. The entire equipment adopts a stainless steel structure and can be configured according to different customer needs. It can meet the high standards of use in clinical, life science, pharmaceutical, P3 biosafety laboratories, etc.

The Trane Biotech VHP sterilization system achieves sterilization by linking with the air conditioning system. Each device has 20 editable programs and can link up to 20 air conditioning units.

As shown in the figure, each equipment adopts 4-6 sets of standard generating modules and 2 sets of parallel runner dehumidification systems. The valves adopt EDPM sealed butterfly valves. The control is controlled by the BMS system linkage. The transportation pipeline adopts anti-corrosion (galvanized layer thickness ≥1 20g/㎡) air duct. Due to the long pipeline transportation, the insulation effect of the transportation pipeline is required to be high. The thermal resistance coefficient R value of the pre-insulated pipeline is greater than 1.2. The entire transportation pipeline will not be affected by the temperature and humidity of the external environment and will not condense during the transportation process.

The BMS system of the air-conditioning system is linked to the VHP main control system. The air-conditioning system needs to be set in disinfection mode. In the disinfection mode, the air-conditioning needs to be reduced in frequency. The air-conditioning air supply adopts a low cycle number scheme to change the gas flow pattern of the clean room and make the clean room air in a turbulent flow state, thereby achieving even distribution of VHP. After entering the disinfection mode, the BMS sends a disinfection command to the VHP sterilization system, and the VHP generation system enters the disinfection-startable state. At this time, the sterilization program of the corresponding unit is started.

VHP transportation pipelines adopt pre-insulated pipelines, which are heat-insulated, anti-corrosion and fire-proof. They are suitable for long-distance hydrogen peroxide pipeline transportation. As shown in the figure below, pre-insulated pipelines can be made into various shapes of transportation pipelines, which are convenient, durable and anti-corrosion.

When transporting VHP through pipelines, you need to pay attention to the connection method and location of the VHP transport pipeline and the main air supply duct. Since the inner wall of the air conditioning duct is made of galvanized material, it will accelerate the degradation of hydrogen peroxide. It is necessary to minimize the pipeline distance before high-concentration VHP enters the room in the sterilization area. The input position must be at the end of the main air supply duct. The connection method between the VHP transport pipeline and the main air supply duct is as shown in the figure below, and the sealing of the connection needs to be considered.

For the situation where multiple HVAC systems share one VHP sterilization system, the location of each system needs to be comprehensively considered, and the total length of each delivery pipeline should not exceed 100 meters, and the number of elbows should be reduced as much as possible.

The schematic diagram of the VHP sterilization scheme of the air conditioning system is as follows:

Air-conditioned room of a pharmaceutical factory

The verification of VHP sterilization effect is carried out according to the following process, which is divided into four stages: parameter development, VHP distribution, biological challenge experiment and exhaust research stage.

The document system and verification execution are strictly implemented in accordance with the V-Model method. A Chinese and English bilingual verification document system is provided to meet the requirements of FDA and EU GMP. Currently, there are many cases of foreign certified customers and biopharmaceutical customers. The document system is carried out according to the following model:

The public engineering system needs the cooperation of Party A. The Trane Bio VHP sterilization system needs to provide 380V/50Hz power supply. The maximum power of the equipment is 15KW. It needs to provide a source of compressed air for valve control. The compressed air requires 6-8 kg pressure.

The control of Trane Biotech's VHP sterilization system is all controlled by Siemens PLC. Products with GMP requirements use a 12.1-inch industrial computer control screen. A variety of application programs are available, such as: LOGA sterilization program, LOGB concentration sterilization and other programs. User rights management is set. The system comes with audit trail, electronic signature function, data and charts can form PDF reports to meet GMP requirements.

The operation interface has a clear introduction, the safety parameters are reasonably controlled, the upper and lower limits of process saturation are set, and the program is stable:

The core components of the equipment are all from big brands. For example, the fans are from German EBM fans, and the fans with cleanliness level requirements and anti-corrosion requirements are all from imported brands.

Control sensors are all selected brands and models that have been tested for a long time. For example, the VHP concentration sensor and temperature and humidity sensor are selected from Finland's VAISALA HPP272 type.