Pharmaceutical workshop sterilization_Hefei Tailing Biotechnology Co., Ltd

Technology Overview

In pharmaceutical workshop environment disinfection, many enterprises use formaldehyde fumigation disinfection and sterilization methods, which are low-cost and have excellent sterilization capabilities. However, the high toxicity of formaldehyde, strong hazards, inconvenient operation, and damage to employee health are being recognized and eliminated by more and more enterprises. Formaldehyde is prohibited in European pharmaceutical companies. [5,6](@ref)

Teling Biotechnology integrates the actual application needs of pharmaceutical enterprise sterilization experts and new technology solutions for pharmaceutical workshop environment disinfection. This introduces the advantages of dry fog hydrogen peroxide sterilizers for pharmaceutical workshop environment disinfection and explains the principle, composition, use, and validation of the Teling Biological Space Dry Fog Sterilization System. [1,2](@ref)

Dry fog hydrogen peroxide sterilization technology has been applied to European pharmaceutical workshop environment disinfection for nearly 20 years. Especially in recent years, under the EU's limited formaldehyde usage environment, dry fog hydrogen peroxide sterilization technology has developed rapidly. Although it cannot be quickly popularized for all categories, the abandonment of formaldehyde sterilization in the EU shows that the entire industry, whether managers or participants, is striving to find a product that can replace formaldehyde for sterilization. [5,8](@ref)

Safety & Eco-friendly

Non-toxic, harmless, no carcinogenic risk, safe for operators, compliant with EU environmental standards [5,6](@ref)

Efficient Sterilization

Log4-Log6 kill rate, broad-spectrum sterilization, capable of killing spores and other stubborn microorganisms [2,3](@ref)

Fast Operation

Entire process takes only 4-6 hours, significantly shortening production downtime and improving efficiency [5,6](@ref)

No Residue

Decomposes into water and oxygen, no harmful residues, no neutralization or cleaning required [5,6](@ref)

What is Dry Fog

Dry fog refers to extremely fine liquid droplets with a diameter of less than 10 microns, possessing unique physical characteristics that make them ideal sterilization carriers. [5,6](@ref)

Dry Fog Size

Dry fog refers to extremely fine particles with diameter less than 10μm [5,6](@ref)

Irregular Motion

Dry fog particles move irregularly (Brownian motion principle) [5,6](@ref)

Non-condensing

Dry droplets do not easily coalesce to form large droplets [5,6](@ref)

Non-adherent

Dry fog particles rebound upon contact with surfaces, not easily adhering [5,6](@ref)

Teling Biotechnology's dry fog sterilization technology solution is the product of collaboration between aerodynamics experts and sterilization technology experts. It was developed using high-tech science and technology, experimental simulation, technical verification, practical application, and pharmaceutical factory monitoring. Its main feature is to make air move at high speed under high pressure, collide with bactericide, and produce dry fog particles with a diameter of less than 10 microns. To achieve complete sterilization effect, kill harmful bacteria, and control harmful microorganisms, it can replace the technical solution of formaldehyde fumigation. [1,2](@ref)

Application Scope

Dry fog hydrogen peroxide sterilization technology is widely used in the following areas: [1,2,6](@ref)

Sterilization of pharmaceutical clean workshop spaces and equipment
Biotechnology laboratories and production lines
Pharmaceutical product production environments
Cell culture rooms and sterile operation rooms
Microbiology laboratories and sterile rooms
Isolators and sterile transfer cabins
Surface disinfection of stainless steel, plastic, glass, etc.
Large area space disinfection of floors, walls, etc.

Pharmaceutical Industry Applications

In the pharmaceutical industry, dry fog hydrogen peroxide sterilization technology is widely used in sterile production workshops, API synthesis areas, preparation filling rooms, and other critical production environments. The system can effectively kill spores and other stubborn microorganisms, ensuring that the pharmaceutical production environment meets GMP requirements. [1,6](@ref)

Teling Biological dry fog sterilization system supports the entire process from R&D to commercial production, providing professional sterile assurance for pharmaceutical enterprises. [1,2](@ref)

Laboratory Applications

In biotechnology laboratories and research institutions, dry fog hydrogen peroxide sterilization technology provides a sterile operating environment for sensitive experiments. The system can be safely used in various experimental scenarios such as PCR laboratories, cell culture rooms, and microbial testing rooms. [3,6](@ref)

Dry fog technology ensures the sterile state of the experimental environment, prevents cross-contamination, and guarantees the accuracy and professionalism of experimental data. [3,9](@ref)

Medical Facilities Applications

In hospitals, clinics and other medical facilities, dry fog hydrogen peroxide sterilization technology can be used for disinfection and sterilization of key areas such as operating rooms, ICU wards, and drug preparation rooms. [4,10](@ref)

The system's rapid and efficient sterilization capability can significantly shorten the disinfection cycle, improve the efficiency of medical facilities, while ensuring the safety of patients and medical staff. [4,10](@ref)

Operation Process

The standard operating procedure for the dry fog hydrogen peroxide sterilization system is as follows: [6](@ref)

1

Equipment Placement

Nozzle away from walls and equipment to ensure even diffusion of dry fog

2

Equipment Preparation

Secure equipment, install appropriate amount of disinfectant, connect power

3

Environment Preparation

Turn off air conditioning, exhaust fresh air, close doors and windows

4

Start Sterilization

Click the start button, the equipment automatically performs dry fog sterilization

5

Completion Treatment

After spraying is completed, let it stand for 90 minutes, exhaust for 1 hour

From the start of disinfection to safe personnel entry, the entire disinfection process takes about 4-6 hours (including ventilation). Compared with traditional formaldehyde fumigation which requires more than 48 hours of exhaust time, dry fog hydrogen peroxide sterilization technology significantly shortens the production downtime and improves production efficiency. [5,6](@ref)

Comparison with Traditional Formaldehyde Fumigation

Comparison Item	Dry Fog Hydrogen Peroxide Sterilization	Formaldehyde Fumigation
Toxicity	Non-toxic, harmless, safe for operators [5,6](@ref)	Strong carcinogenicity, can be inherited across generations, causing fetal malformations [5,6](@ref)
Sterilization Effect	Log4-Log6 kill rate, broad-spectrum efficiency [2,3](@ref)	Sterilization efficacy meets requirements but cannot fully achieve Log6 [5](@ref)
Sterilization Time	Complete process 3-6 hours, quick production recovery [5,6](@ref)	Requires at least 48 hours of ventilation before production can resume [5,6](@ref)
Residue Issue	No residue on surfaces or in space, no cleaning required [5,6](@ref)	Need to clean white crystals, and it's difficult to completely remove [5](@ref)
Operation Convenience	Simple operation, high degree of automation [2,10](@ref)	Complex operation requires professional personnel [5](@ref)
Environmental Friendliness	Decomposes into water and oxygen, environmentally friendly [5,6](@ref)	Toxic and harmful, serious environmental pollution [5,6](@ref)
Regulatory Compliance	Compliant with EU and international standards, widely recommended [5,8](@ref)	Banned in EU, gradually being phased out [5](@ref)

Verification and Certification

Sterilization effect verification of hydrogen peroxide dry fog sterilization system: [6](@ref)

The sterilization effect of the hydrogen peroxide atomization sterilization system can be verified. According to the Chinese Pharmacopoeia, using Bacillus subtilis as the challenge test bacterium, a kill rate of 10³-10⁶ can be achieved, that is, a reduction of 3-6 logarithmic units, which can prove the system's ability to kill various microorganisms during the space sterilization and purification process. [6](@ref)

China GMP Certification

EU CE Certification

ISO 14644

USP Standards

EPA Certification

Dry Fog Hydrogen Peroxide Sterilization Technology